Difference between revisions of "Part:BBa K5198000"
Line 5: Line 5:
 
Ectodomain of human CD19 coreceptor. In its native form, CD19 is a coreceptor in the B-cell antigen receptor complex on B-lymphocytes. CD19 is used as a marker of B-cell development and is one of the most popular targets in cell therapies treating most types of leukemia. This part can be used as a soluble ligand that triggers activation of receptors capable of dimerization. CD19ecto has been shown to exist in monomeric and dimeric form. The dimer form is suggested to be responsible for activation of receptors.  
 
Ectodomain of human CD19 coreceptor. In its native form, CD19 is a coreceptor in the B-cell antigen receptor complex on B-lymphocytes. CD19 is used as a marker of B-cell development and is one of the most popular targets in cell therapies treating most types of leukemia. This part can be used as a soluble ligand that triggers activation of receptors capable of dimerization. CD19ecto has been shown to exist in monomeric and dimeric form. The dimer form is suggested to be responsible for activation of receptors.  
  
−
<html><img src="https://static.igem.wiki/teams/5198/car-dimerization.png"/></html>
+
<html>
 +
<head>
 +
    <meta charset="UTF-8">
 +
    <meta name="viewport" content="width=device-width, initial-scale=1.0">
 +
    <title>Right Aligned Image</title>
 +
    <style>
 +
        .right-image {
 +
            float: right;
 +
        }
 +
    </style>
 +
</head>
 +
 
 +
<img src="https://static.igem.wiki/teams/5198/car-dimerization.png" class = "right-image">
 +
 
 +
</html>
  
 
<!-- Add more about the biology of this part here
 
<!-- Add more about the biology of this part here

Revision as of 15:14, 30 August 2024


CD19ecto

Ectodomain of human CD19 coreceptor. In its native form, CD19 is a coreceptor in the B-cell antigen receptor complex on B-lymphocytes. CD19 is used as a marker of B-cell development and is one of the most popular targets in cell therapies treating most types of leukemia. This part can be used as a soluble ligand that triggers activation of receptors capable of dimerization. CD19ecto has been shown to exist in monomeric and dimeric form. The dimer form is suggested to be responsible for activation of receptors.

Right Aligned Image

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI.rc site found at 225
    Illegal SapI.rc site found at 61


References