Difference between revisions of "Part:BBa K4960011"

Revision as of 03:36, 12 October 2023 (view source) Palpitate (Talk | contribs) ← Older edit		Latest revision as of 14:06, 12 October 2023 (view source) CirceTerry (Talk | contribs) (→‎Profile)
Line 6:		Line 6:
	Name: pvc11<br>		Name: pvc11<br>
	Base Pairs: 2187bp<br>		Base Pairs: 2187bp<br>
−	Origin: Photorhabdus<br>	+	Origin: <i>Photorhabdus</i><br>
	Properties: Pvc11 is a part of pvc baseplate.<br>		Properties: Pvc11 is a part of pvc baseplate.<br>
	<!-- Add more about the biology of this part here-->		<!-- Add more about the biology of this part here-->
		+
	===Usage and Biology===		===Usage and Biology===
	Photorhabdus virulence cassette (PVC) is one group of extracellular Contractile injection systems (CISs) that are cell-puncturing nanodevices for targeted delivery of proteins .[1]Structurally similar to other CISs, PVCs are also macromolecular complexes containing a rigid tube structure housed in a contractile sheath, which is anchored to a baseplate and sharpened by a spike protein.[2]('''Figure1''')<br>		Photorhabdus virulence cassette (PVC) is one group of extracellular Contractile injection systems (CISs) that are cell-puncturing nanodevices for targeted delivery of proteins .[1]Structurally similar to other CISs, PVCs are also macromolecular complexes containing a rigid tube structure housed in a contractile sheath, which is anchored to a baseplate and sharpened by a spike protein.[2]('''Figure1''')<br>

---

Latest revision as of 14:06, 12 October 2023

pvc11
Pvc11 is a part of pvc baseplate.

Profile

Name: pvc11
Base Pairs: 2187bp
Origin: Photorhabdus
Properties: Pvc11 is a part of pvc baseplate.

Usage and Biology

Photorhabdus virulence cassette (PVC) is one group of extracellular Contractile injection systems (CISs) that are cell-puncturing nanodevices for targeted delivery of proteins .[1]Structurally similar to other CISs, PVCs are also macromolecular complexes containing a rigid tube structure housed in a contractile sheath, which is anchored to a baseplate and sharpened by a spike protein.[2](Figure1)

Figure 1. Schematic of the PVCpnf locus. It contains 16 structural and accessory genes , followed by two payload genes (Pdp1 and Pnf, in red) and four putative regulatory genes (in pink).

In the assembled wedges, six copies of Pvc11-Pvc12 heterodimers form a hexagonal ring through the dimerization between the domain V of pvc11 and the domain III of pvc12 from a neighboring heterodimer.
Using an extrusion for the interactions with adjacent domains with pvc11.
One part involved in the association between the wedges and the central hub.

Sequence and Features

References

[1]Kreitz J, Friedrich MJ, Guru A, Lash B, Saito M, Macrae RK, Zhang F. Programmable protein delivery with a bacterial contractile injection system. Nature. 2023 Apr;616(7956):357-364. doi: 10.1038/s41586-023-05870-7. Epub 2023 Mar 29.
[2]Jiang F, Li N, Wang X, Cheng J, Huang Y, Yang Y, Yang J, Cai B, Wang YP, Jin Q, Gao N. Cryo-EM Structure and Assembly of an Extracellular Contractile Injection System. Cell. 2019 Apr 4;177(2):370-383.e15. doi: 10.1016/j.cell.2019.02.020. Epub 2019 Mar 21.