Difference between revisions of "Part:BBa K4990013"

 
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  As HokB belongs to the Hok/Gef family, it is predicted to be a single-span membrane peptide，which is a single-span membrane peptide with a long, negatively charged C-terminal periplasmic tail and a short, positively charged N terminus extending in the cytoplasm. HokB has the ability to selectively insert into the cellular membrane and aggregate to create pores with a diameter of around 0.64nm, which alters the membrane potential, depolarize the membrane, hinder ATP synthesis, decrease the cell's energy ratio, and lead to ATP leakage,[8] ultimately resulting in cell death.
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As HokB belongs to the Hok/Gef family, it is predicted to be a single-span membrane peptide，which is a single-span membrane peptide with a long, negatively charged C-terminal periplasmic tail and a short, positively charged N terminus extending in the cytoplasm. HokB has the ability to selectively insert into the cellular membrane and aggregate to create pores with a diameter of around 0.64nm, which alters the membrane potential, depolarize the membrane, hinder ATP synthesis, decrease the cell's energy ratio, and lead to ATP leakage,[8] ultimately resulting in cell death.
  
 
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Revision as of 12:35, 12 October 2023


HokB


As HokB belongs to the Hok/Gef family, it is predicted to be a single-span membrane peptide，which is a single-span membrane peptide with a long, negatively charged C-terminal periplasmic tail and a short, positively charged N terminus extending in the cytoplasm. HokB has the ability to selectively insert into the cellular membrane and aggregate to create pores with a diameter of around 0.64nm, which alters the membrane potential, depolarize the membrane, hinder ATP synthesis, decrease the cell's energy ratio, and lead to ATP leakage,[8] ultimately resulting in cell death.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]