Difference between revisions of "Part:BBa K4855000"

 
 
Line 4: Line 4:
  
 
This part comprises the coding sequence of a synthetic hybrid MBL enzyme capable of degrading all beta-lactams except monobactams. It incorporates all the mutations found in the NDM-2 and NDM-5 variants, which were identified as having the highest activity against meropenem based on literature data. The iGEM Bulgaria 2023 team employed this component in their enhanced CADABRA cocktail.
 
This part comprises the coding sequence of a synthetic hybrid MBL enzyme capable of degrading all beta-lactams except monobactams. It incorporates all the mutations found in the NDM-2 and NDM-5 variants, which were identified as having the highest activity against meropenem based on literature data. The iGEM Bulgaria 2023 team employed this component in their enhanced CADABRA cocktail.
 +
 +
  
 
<!-- Add more about the biology of this part here
 
<!-- Add more about the biology of this part here

Latest revision as of 21:59, 11 October 2023


blaNDM-2&5

This part comprises the coding sequence of a synthetic hybrid MBL enzyme capable of degrading all beta-lactams except monobactams. It incorporates all the mutations found in the NDM-2 and NDM-5 variants, which were identified as having the highest activity against meropenem based on literature data. The iGEM Bulgaria 2023 team employed this component in their enhanced CADABRA cocktail.


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]