Difference between revisions of "Part:BBa K4656002"

Revision as of 12:37, 5 October 2023

TPH

TPH also plays a vital role in the synthesis of serotonin, where the rate-limiting step is catalyzed by TPH to convert tryptophan (an essential amino acid) to 5-hydroxytryptophan (5-HTP).

The synthesis of 5-HT

Usage and Biology

As a neurotransmitter, serotonin can play the role of intestinal motility. If its secretion is insufficient, it can easily lead to the decline of intestinal motility, and then lead to chronic constipation. Therefore, promoting TPH expression is conducive to the treatment of chronic constipation. Experimental results about our 5-HT producing circuit can be found in our composite part BBa K4656007.

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
INCOMPATIBLE WITH RFC[12]
Illegal NheI site found at 898
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
INCOMPATIBLE WITH RFC[25]
Illegal AgeI site found at 673
1000
INCOMPATIBLE WITH RFC[1000]
Illegal SapI.rc site found at 240

@@ Line 3: / Line 3: @@
 <partinfo>BBa_K4656002 short</partinfo>
-TPH also plays a vital role in the synthesis of serotonin, in which the rate-limiting step is catalyzed by TPH，converting tryptophan (an essential amino acid) to 5-hydroxytryptophan (5-HTP).
+TPH also plays a vital role in the synthesis of serotonin, where the rate-limiting step is catalyzed by TPH to convert tryptophan (an essential amino acid) to 5-hydroxytryptophan (5-HTP).
 <html><BR><BR><center><img style="display: block;-webkit-user-select: none;margin: auto;cursor: zoom-in;background-color: hsl(0,0%,90%);transition: background-color 300ms;" src="https://static.igem.wiki/teams/4656/wiki/tdc-tph.jpg" width="600" height="200"></center></html>