Difference between revisions of "Part:BBa K4586030"

Revision as of 07:05, 4 October 2023

Citrullinated vimentin

Description

These are synthetic citrullinated peptide designed to detect and measure specific antibodies that are elevated in autoimmune diseases especially rheumatoid arthritis.

Usage

We initially used this part in our design to be the ligand binding domain in the extracellular part of our Syn notch receptor to interact with the auto-reactive B-cell receptor that secrete ACPA and transmit the signal of this selective binding inside the cell to express our therapeutic cargo within the modified exosomes that target the auto reactive B-cells.

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
COMPATIBLE WITH RFC[1000]

@@ Line 5: / Line 5: @@
 ==Description==
-Theses are synthetic citrullinated peptide designed to detect anti specific antibodies that are elevated in autoimmune diseases especially rheumatoid arthritis.
+These are synthetic citrullinated peptide designed to detect and measure specific antibodies that are elevated in autoimmune diseases especially rheumatoid arthritis.
 ==Usage==
-We initially used this part inn our design to be the ligand binding domain in the the extracellular part of our Syn notch receptor to interact with the auto-reactive B-cell receptor that secrete ACPA and transmit the signal of this selective binding inside the cell to express our therapeutic cargo within the modified exosomes that target the auto reactive B-cells.
+We initially used this part in our design to be the ligand binding domain in the extracellular part of our Syn notch receptor to interact with the auto-reactive B-cell receptor that secrete ACPA and transmit the signal of this selective binding inside the cell to express our therapeutic cargo within the modified exosomes that target the auto reactive B-cells.
 <!-- Add more about the biology of this part here