Difference between revisions of "Part:BBa K4989000"
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==<strong>Acetyl-CoA C-acetyltransferase <i>(thl)</i></strong>== | ==<strong>Acetyl-CoA C-acetyltransferase <i>(thl)</i></strong>== | ||
| − | + | The <i>thl</i> gene codes for an enzyme named <em>acetyl-CoA C-acetyltransferase</em> which belongs to the family of <i>thiolases</i>. This is the key enzyme for the condensation of two molecules of acetyl-CoA, which are produced from the glycolysis path, and the acetoacetyl-CoA production [3]. This is a reaction that thermodynamically itself is not favored. It starts with the acylation of a nucleophilic cysteine at the active site by acetyl-CoA (or a different acyl group) with the release of the CoA group. Then the acyl group is transferred to an acetyl-CoA molecule. | |
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| + | <p>The chemical reactions that take place are shown below: | ||
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| + | (1) acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA | ||
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| + | (1a) acetyl-CoA C-acyltransferase-S-acyl-L-cyteine + acetyl-CoA = 3-oxoacyl-CoA + acetyl-CoA C-acyltransferase-L-cyteine | ||
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| + | (1b) acyl-CoA + acetyl-CoA C-acyltransferase-L-cyteine = acetyl-CoA C-acyltransferase-S-acyl-L-cyteine + CoA </p> | ||
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==<strong>Alternative names of the enzyme</strong>== | ==<strong>Alternative names of the enzyme</strong>== | ||
Revision as of 14:04, 3 October 2023
Contents
Acetyl-CoA C-acetyltransferase (thl)
The thl gene codes for an enzyme named acetyl-CoA C-acetyltransferase which belongs to the family of thiolases. This is the key enzyme for the condensation of two molecules of acetyl-CoA, which are produced from the glycolysis path, and the acetoacetyl-CoA production [3]. This is a reaction that thermodynamically itself is not favored. It starts with the acylation of a nucleophilic cysteine at the active site by acetyl-CoA (or a different acyl group) with the release of the CoA group. Then the acyl group is transferred to an acetyl-CoA molecule.
The chemical reactions that take place are shown below: (1) acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA (1a) acetyl-CoA C-acyltransferase-S-acyl-L-cyteine + acetyl-CoA = 3-oxoacyl-CoA + acetyl-CoA C-acyltransferase-L-cyteine (1b) acyl-CoA + acetyl-CoA C-acyltransferase-L-cyteine = acetyl-CoA C-acyltransferase-S-acyl-L-cyteine + CoA