Difference between revisions of "Part:BBa K4586009"

Revision as of 16:18, 20 September 2023

lamp2b

Part Description

This part is a gene coding of a family of membrane glycoproteins called Lysosome-associated membrane protein 2 (LAMP2), through modification of the outer membrane domain of the lamp2b. Our target protein can be delivered to the exosome's surface using lamp 2b.

Usage

This part is used to express citrullinated vimentin on the exosomal surface to increase the exosomes' affinity for the autoreactive B-cells, as this transmembrane protein is unique to the membrane of exosomes and lysosomes, so the likelihood of exosome and B-cell fusion has significantly increased. Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
COMPATIBLE WITH RFC[1000]

@@ Line 4: / Line 4: @@
 ==Part Description==
-It is the transmembrane protein known as lysosome-associated membrane glycoprotein 2b, which is unique to the membrane of exosomes. LAMP2B mutation can cause danon disease that manifests with the clinical triad of cardiomyopathy, skeletal myopathy, and intellectual disability
+This part is a gene coding of a family of membrane glycoproteins called Lysosome-associated membrane protein 2 (LAMP2), through modification of the outer membrane domain of the lamp2b. Our target protein can be delivered to the exosome's surface using lamp 2b.
 ==Usage==
 This part is used to express citrullinated vimentin on the exosomal surface to increase the exosomes' affinity for the autoreactive B-cells, as this transmembrane protein is unique to the membrane of exosomes and lysosomes, so the likelihood of exosome and B-cell fusion has significantly increased.