Difference between revisions of "Part:BBa K4586009"
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<partinfo>BBa_K4586009 short</partinfo> | <partinfo>BBa_K4586009 short</partinfo> | ||
| − | It is the transmembrane protein known as lysosome associated membrane glycoprotein 2b, which is unique to the membrane of exosomes. | + | ==Part Description== |
| − | + | It is the transmembrane protein known as lysosome-associated membrane glycoprotein 2b, which is unique to the membrane of exosomes. LAMP2B mutation can cause danon disease that manifests with the clinical triad of cardiomyopathy, skeletal myopathy, and intellectual disability | |
| + | ==Usage== | ||
| + | This part is used to express citrullinated vimentin on the exosomal surface to increase the exosomes' affinity for the autoreactive B-cells, as this transmembrane protein is unique to the membrane of exosomes and lysosomes, so the likelihood of exosome and B-cell fusion has significantly increased. | ||
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===Usage and Biology=== | ===Usage and Biology=== | ||
Revision as of 09:43, 20 September 2023
lamp2b
Part Description
It is the transmembrane protein known as lysosome-associated membrane glycoprotein 2b, which is unique to the membrane of exosomes. LAMP2B mutation can cause danon disease that manifests with the clinical triad of cardiomyopathy, skeletal myopathy, and intellectual disability
Usage
This part is used to express citrullinated vimentin on the exosomal surface to increase the exosomes' affinity for the autoreactive B-cells, as this transmembrane protein is unique to the membrane of exosomes and lysosomes, so the likelihood of exosome and B-cell fusion has significantly increased. Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]