|
|
| Line 7: |
Line 7: |
| | | | |
| | ===Design Notes=== | | ===Design Notes=== |
| − |
| |
| − | It is mainly regulated by the transcriptional activator (FNR). In the absence of oxygen, the FNR binds to the [4Fe-4S]2+ cluster to generate a transcriptionally active homodimer. However, in the presence of oxygen, the [4Fe-4S]2+ cluster is degraded and the FNR dimer dissociates into inactive monomers.
| |
| | | | |
| | | | |
| Line 15: |
Line 13: |
| | | | |
| | ===References=== | | ===References=== |
| − | <i>
| |
| − | 1 Yu B, Yang M, Shi L, et al. Explicit hypoxia targeting with tumor suppression by creating an
| |
| − | "obligate" anaerobic Salmonella Typhimurium strain. Sci Rep. 2012;2:436. doi:10.1038/srep00436
| |
| − |
| |
| − |
| |
| − | 2 Crack JC, Jervis AJ, Gaskell AA, et al. Signal perception by FNR: the role of the iron-sulfur
| |
| − | cluster. Biochem Soc Trans. Dec 2008;36(Pt 6):1144-8. doi:10.1042/bst0361144
| |
| − |
| |
| − |
| |
| − | 3 Goers L, Ainsworth C, Goey CH, Kontoravdi C, Freemont PS, Polizzi KM. Whole-cell
| |
| − | Escherichia coli lactate biosensor for monitoring mammalian cell cultures during biopharmaceutical
| |
| − | production. Biotechnol Bioeng. 2017;114(6):1290-1300. doi:10.1002/bit.26254
| |
| − | </i>
| |
