Difference between revisions of "Part:BBa K4656002"

Revision as of 15:44, 9 September 2023

TPH

Tph plays an important role in the synthesis of serotonin (5-hydroxytryptamine, 5-HT), in which the rate-limiting step is catalyzed by TPH， converting tryptophan (an essential amino acid) to 5-hydroxytryptophan (5-HTP).

Usage and Biology

As a neurotransmitter, serotonin can play the role of intestinal motility. If its secretion is insufficient, it can easily lead to the decline of intestinal motility, and then lead to chronic constipation. Therefore, promoting TPH expression is conducive to the treatment of chronic constipation.

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
INCOMPATIBLE WITH RFC[12]
Illegal NheI site found at 898
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
INCOMPATIBLE WITH RFC[25]
Illegal AgeI site found at 673
1000
INCOMPATIBLE WITH RFC[1000]
Illegal SapI.rc site found at 240

@@ Line 3: / Line 3: @@
 <partinfo>BBa_K4656002 short</partinfo>
-Tph1 is the gene encoding tryptophan hydroxylase (TPH), which plays an important role in the synthesis of serotonin (5-hydroxytryptamine, 5-HT), in which the rate-limiting step is catalyzed by TPH. The Tph1 gene expresses the TPH1 protein, which converts tryptophan (an essential amino acid) to 5-hydroxytryptophan (5-HTP).
+Tph plays an important role in the synthesis of serotonin (5-hydroxytryptamine, 5-HT), in which the rate-limiting step is catalyzed by TPH， converting tryptophan (an essential amino acid) to 5-hydroxytryptophan (5-HTP).
 ===Usage and Biology===
-As a neurotransmitter, serotonin can play the role of intestinal motility. If its secretion is insufficient, it can easily lead to the decline of intestinal motility, and then lead to chronic constipation. Therefore, constructing plasmids introducing Tph1 gene and promoting TPH expression is conducive to the treatment of chronic constipation.
+As a neurotransmitter, serotonin can play the role of intestinal motility. If its secretion is insufficient, it can easily lead to the decline of intestinal motility, and then lead to chronic constipation. Therefore, promoting TPH expression is conducive to the treatment of chronic constipation.
 ===Sequence and Features===