Difference between revisions of "Part:BBa K4656001"
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Tdc is the gene encoding tryptophan decarboxylase (TDC), which can remove the carboxyl group from 5-hydroxytryptophan (5-HTP) and convert it into serotonin (5-hydroxytryptophan, 5-HT) molecules. Tryptophan decarboxylase exists widely in animals and plants, especially in the central nervous system and gastrointestinal tract. Among them, 5-HTP is a precursor substance of neurotransmitter, while serotonin is an important neurotransmitter, similar to intestinal motor in terms of intestinal physiological function, and plays an important role in alleviating chronic constipation. | Tdc is the gene encoding tryptophan decarboxylase (TDC), which can remove the carboxyl group from 5-hydroxytryptophan (5-HTP) and convert it into serotonin (5-hydroxytryptophan, 5-HT) molecules. Tryptophan decarboxylase exists widely in animals and plants, especially in the central nervous system and gastrointestinal tract. Among them, 5-HTP is a precursor substance of neurotransmitter, while serotonin is an important neurotransmitter, similar to intestinal motor in terms of intestinal physiological function, and plays an important role in alleviating chronic constipation. | ||
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===Usage and Biology=== | ===Usage and Biology=== | ||
Revision as of 14:57, 7 September 2023
TDC
Tdc is the gene encoding tryptophan decarboxylase (TDC), which can remove the carboxyl group from 5-hydroxytryptophan (5-HTP) and convert it into serotonin (5-hydroxytryptophan, 5-HT) molecules. Tryptophan decarboxylase exists widely in animals and plants, especially in the central nervous system and gastrointestinal tract. Among them, 5-HTP is a precursor substance of neurotransmitter, while serotonin is an important neurotransmitter, similar to intestinal motor in terms of intestinal physiological function, and plays an important role in alleviating chronic constipation.
Usage and Biology
Our project uses the introduction of Tdc sequences and inducing their expression to produce serotonin to test their efficacy in treating constipation. The original sequence of TDC was derived from the genome of the organism Oryza sativa Japonica Group (Japanese rice).
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21INCOMPATIBLE WITH RFC[21]Illegal BglII site found at 1248
Illegal BamHI site found at 732
Illegal BamHI site found at 834 - 23COMPATIBLE WITH RFC[23]
- 25INCOMPATIBLE WITH RFC[25]Illegal NgoMIV site found at 340
Illegal NgoMIV site found at 775
Illegal NgoMIV site found at 1330
Illegal AgeI site found at 478
Illegal AgeI site found at 1402 - 1000COMPATIBLE WITH RFC[1000]