Difference between revisions of "Part:BBa K4656001"

 
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  Tdc is the gene encoding tryptophan decarboxylase (TDC), which can remove the carboxyl group from 5-hydroxytryptophan (5-HTP) and convert it into serotonin (5-hydroxytryptophan, 5-HT) molecules. Tryptophan decarboxylase exists widely in animals and plants, especially in the central nervous system and gastrointestinal tract. Among them, 5-HTP is a precursor substance of neurotransmitter, while serotonin is an important neurotransmitter, similar to intestinal motor in terms of intestinal physiological function, and plays an important role in alleviating chronic constipation.  
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Tdc is the gene encoding tryptophan decarboxylase (TDC), which can remove the carboxyl group from 5-hydroxytryptophan (5-HTP) and convert it into serotonin (5-hydroxytryptophan, 5-HT) molecules. Tryptophan decarboxylase exists widely in animals and plants, especially in the central nervous system and gastrointestinal tract. Among them, 5-HTP is a precursor substance of neurotransmitter, while serotonin is an important neurotransmitter, similar to intestinal motor in terms of intestinal physiological function, and plays an important role in alleviating chronic constipation.  
  
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  Our project uses the introduction of Tdc sequences and inducing their expression to produce serotonin to test their efficacy in treating constipation. The original sequence of TDC was derived from the genome of the organism Oryza sativa Japonica Group (Japanese rice).
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Our project uses the introduction of Tdc sequences and inducing their expression to produce serotonin to test their efficacy in treating constipation. The original sequence of TDC was derived from the genome of the organism Oryza sativa Japonica Group (Japanese rice).
  
 
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Revision as of 00:42, 9 August 2023


TDC


Tdc is the gene encoding tryptophan decarboxylase (TDC), which can remove the carboxyl group from 5-hydroxytryptophan (5-HTP) and convert it into serotonin (5-hydroxytryptophan, 5-HT) molecules. Tryptophan decarboxylase exists widely in animals and plants, especially in the central nervous system and gastrointestinal tract. Among them, 5-HTP is a precursor substance of neurotransmitter, while serotonin is an important neurotransmitter, similar to intestinal motor in terms of intestinal physiological function, and plays an important role in alleviating chronic constipation.

Our project uses the introduction of Tdc sequences and inducing their expression to produce serotonin to test their efficacy in treating constipation. The original sequence of TDC was derived from the genome of the organism Oryza sativa Japonica Group (Japanese rice).

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal BglII site found at 1248
    Illegal BamHI site found at 732
    Illegal BamHI site found at 834
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal NgoMIV site found at 340
    Illegal NgoMIV site found at 775
    Illegal NgoMIV site found at 1330
    Illegal AgeI site found at 478
    Illegal AgeI site found at 1402
  • 1000
    COMPATIBLE WITH RFC[1000]