Difference between revisions of "Part:BBa K4165258"
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<partinfo>BBa_K4165258 short</partinfo> | <partinfo>BBa_K4165258 short</partinfo> | ||
| − | + | This composite part encodes for TDrev28 which binds to misfolded tau protein (BBa_K4165006) tagged with a GST tag (BBa_K4165070). | |
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===Usage and Biology=== | ===Usage and Biology=== | ||
Revision as of 15:03, 12 October 2022
GST-TD28REV
This composite part encodes for TDrev28 which binds to misfolded tau protein (BBa_K4165006) tagged with a GST tag (BBa_K4165070).
Usage and Biology
Td28rev is a synthetic peptide designed to bind to microtubule associated protein tau (MAPT) at the PHF motif which is reported to drive the accumulation of paired helical filaments form of tau resulting in tau aggregates related diseases which are mostly related to dementia. It is fused to GST tag for purification.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000INCOMPATIBLE WITH RFC[1000]Illegal SapI.rc site found at 85