Difference between revisions of "Part:BBa K4437004"
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This part contains the coding sequence for the antimicrobial region of NisQ, a variant of nisin. | This part contains the coding sequence for the antimicrobial region of NisQ, a variant of nisin. | ||
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Derived from Lactococcus lactis, nisin is a food-safe, antimicrobial peptide (AMP) that targets a wide range of gram positive bacteria by binding to lipid II on the pathogens membrane, creating a pore, and causing cell death. Literature suggests that nisin Q (NisQ) demonstrates greater antimicrobial and antioxidant activity against pathogens compared to other variants of nisin, such as NisA (BBa_K1365000). Nisin’s optimal pH stability is between 2 and 7 but can maintain its antibacterial activity up to a pH of 12, and can also retain its antimicrobial activity at temperatures of 120oC. | Derived from Lactococcus lactis, nisin is a food-safe, antimicrobial peptide (AMP) that targets a wide range of gram positive bacteria by binding to lipid II on the pathogens membrane, creating a pore, and causing cell death. Literature suggests that nisin Q (NisQ) demonstrates greater antimicrobial and antioxidant activity against pathogens compared to other variants of nisin, such as NisA (BBa_K1365000). Nisin’s optimal pH stability is between 2 and 7 but can maintain its antibacterial activity up to a pH of 12, and can also retain its antimicrobial activity at temperatures of 120oC. | ||
Revision as of 04:19, 12 October 2022
Antimicrobial region of nisin Q
This part contains the coding sequence for the antimicrobial region of NisQ, a variant of nisin.
Derived from Lactococcus lactis, nisin is a food-safe, antimicrobial peptide (AMP) that targets a wide range of gram positive bacteria by binding to lipid II on the pathogens membrane, creating a pore, and causing cell death. Literature suggests that nisin Q (NisQ) demonstrates greater antimicrobial and antioxidant activity against pathogens compared to other variants of nisin, such as NisA (BBa_K1365000). Nisin’s optimal pH stability is between 2 and 7 but can maintain its antibacterial activity up to a pH of 12, and can also retain its antimicrobial activity at temperatures of 120oC.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25INCOMPATIBLE WITH RFC[25]Illegal AgeI site found at 37
- 1000COMPATIBLE WITH RFC[1000]
This sequence contains only the antimicrobial region of the peptide nisin Q.