Difference between revisions of "Part:BBa K4437004"

Revision as of 04:09, 12 October 2022

Antimicrobial region of nisin Q

This part contains the coding sequence for the antimicrobial region of NisQ, a variant of nisin.

Sequence and Features

Assembly Compatibility:

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-===Usage and Biology===
+Derived from Lactococcus lactis, nisin is a food-safe, antimicrobial peptide (AMP) that targets a wide range of gram positive bacteria by binding to lipid II on the pathogens membrane, creating a pore, and causing cell death. Literature suggests that nisin Q (NisQ) demonstrates greater antimicrobial and antioxidant activity against pathogens compared to other variants of nisin, such as NisA (BBa_K1365000). Nisin’s optimal pH stability is between 2 and 7 but can maintain its antibacterial activity up to a pH of 12, and can also retain its antimicrobial activity at temperatures of 120oC.
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