Difference between revisions of "Part:BBa K4165195"
(→Dry lab) |
|||
| Line 15: | Line 15: | ||
===Dry lab=== | ===Dry lab=== | ||
<p style=" font-weight: bold; font-size:14px;"> Modeling </p> | <p style=" font-weight: bold; font-size:14px;"> Modeling </p> | ||
| − | The peptide was modeled by several software (Alphafold - Apptest - Pepfold) and the best model from Apptest. | + | The peptide was modeled by several software (Alphafold - Apptest - Pepfold) and the best model was obtained from Apptest. |
<html> | <html> | ||
| Line 22: | Line 22: | ||
Figure 1.: Amyloid-beta (34-42) top model visualized by pymol. | Figure 1.: Amyloid-beta (34-42) top model visualized by pymol. | ||
| − | |||
| − | |||
| − | |||
===References=== | ===References=== | ||
Latest revision as of 19:55, 11 October 2022
Amyloid beta peptide 15 (Aβ 34-42)
This part encodes a part of the Amyloid 𝛽 fragment (34-42) which has the ability to bind to A𝛽 plaques inside the brain.
Usage and Biology
Segments of amyloid beta fibrils are widely used as a recognition sequence for amyloid beta plaques inside the brain, this is due to the homotypic interactions in the C-terminus of fibrils. This peptide starts from amino acid 29 to 42 of the fibril. This binding peptide starts from amino acid 34 to 42.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
Dry lab
Modeling
The peptide was modeled by several software (Alphafold - Apptest - Pepfold) and the best model was obtained from Apptest.
Figure 1.: Amyloid-beta (34-42) top model visualized by pymol.
References
1-Zhao, Y., Cai, J., Liu, Z., Li, Y., Zheng, C., Zheng, Y., ... & Liu, Y. (2018). Nanocomposites inhibit the formation, mitigate the neurotoxicity, and facilitate the removal of β-amyloid aggregates in Alzheimer’s disease mice. Nano letters, 19(2), 674-683.