Difference between revisions of "Part:BBa K4165143"
 
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<partinfo>BBa_K4165143 short</partinfo>
 
<partinfo>BBa_K4165143 short</partinfo>
  
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Tau binding peptide targeting the PHF seed of Tau
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A synthetic peptide that is used for targeting misfolded tau protein (BBa_K4165009) as it binds to PHF6 of tau fibrils.
  
 
===Usage and Biology===
 
===Usage and Biology===
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KNT is a peptide tested as an inhibitor for tau aggregation. Its half maximal concentration for tau fibril formation inhibition is 182.8 μM, it can bind to tau at PHF seed (VQIVYK), its amino acid sequence is KNTPQHRKLRLS. It can penetrate cell membrane and cytosol of N2a cells
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KNT (KNTPQHRKLRLS) is a peptide tested as an inhibitor for tau aggregation. Its half maximal concentration for tau fibril formation inhibition is 182.8 μM, and it can bind to tau at PHF seed (VQIVYK). The peptide can penetrate cell membrane and cytosol of N2a cells
  
  

Latest revision as of 13:19, 11 October 2022


KNT Peptide

A synthetic peptide that is used for targeting misfolded tau protein (BBa_K4165009) as it binds to PHF6 of tau fibrils.

Usage and Biology

KNT (KNTPQHRKLRLS) is a peptide tested as an inhibitor for tau aggregation. Its half maximal concentration for tau fibril formation inhibition is 182.8 μM, and it can bind to tau at PHF seed (VQIVYK). The peptide can penetrate cell membrane and cytosol of N2a cells


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]

Reference

1. Dammers, C., Yolcu, D., Kukuk, L., Willbold, D., Pickhardt, M., Mandelkow, E., ... & Funke, S. A. (2016). Selection and Characterization of Tau Binding ᴅ-Enantiomeric Peptides with Potential for Therapy of Alzheimer Disease. PLoS One, 11(12), e0167432.