Difference between revisions of "Part:BBa K4165011"
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Ubiquitin-conjugating E2 ligase has a role in the ubiquitination cascade for protein degradation. | Ubiquitin-conjugating E2 ligase has a role in the ubiquitination cascade for protein degradation. | ||
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| + | ===Usage and Biology=== | ||
| + | encodes a member of the E2 ubiquitin-conjugating enzyme family and is involved in the ubiquitin-proteasome pathway, this ligase will be used in the project in the Trim21 system as a type of ligase essential for the ubiquitin cascade | ||
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2- David, Y., Ziv, T., Admon, A., & Navon, A. (2010). The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. The Journal of biological chemistry, 285(12), 8595–8604. https://doi.org/10.1074/jbc.M109.089003 | 2- David, Y., Ziv, T., Admon, A., & Navon, A. (2010). The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. The Journal of biological chemistry, 285(12), 8595–8604. https://doi.org/10.1074/jbc.M109.089003 | ||
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| + | 3- Li, J., Xu, C., Zhang, J., Jin, C., Shi, X., Zhang, C., ... & Xu, L. (2021). Identification of miRNA-target gene pairs in the parietal and frontal lobes of the brain in patients with Alzheimer’s Disease using bioinformatic analyses. Neurochemical Research, 46(4), 964-979. | ||
Revision as of 12:29, 10 October 2022
UBE2N
Ubiquitin-conjugating E2 ligase has a role in the ubiquitination cascade for protein degradation.
Usage and Biology
encodes a member of the E2 ubiquitin-conjugating enzyme family and is involved in the ubiquitin-proteasome pathway, this ligase will be used in the project in the Trim21 system as a type of ligase essential for the ubiquitin cascade
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21INCOMPATIBLE WITH RFC[21]Illegal BglII site found at 221
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
Refrences
1- Komander D. (2009). The emerging complexity of protein ubiquitination. Biochemical Society transactions, 37(Pt 5), 937–953. https://doi.org/10.1042/BST0370937
2- David, Y., Ziv, T., Admon, A., & Navon, A. (2010). The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. The Journal of biological chemistry, 285(12), 8595–8604. https://doi.org/10.1074/jbc.M109.089003
3- Li, J., Xu, C., Zhang, J., Jin, C., Shi, X., Zhang, C., ... & Xu, L. (2021). Identification of miRNA-target gene pairs in the parietal and frontal lobes of the brain in patients with Alzheimer’s Disease using bioinformatic analyses. Neurochemical Research, 46(4), 964-979.