Difference between revisions of "Part:BBa K4165230"
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===Usage and Biology=== | ===Usage and Biology=== | ||
| + | According to Previous Research results, Our binding peptides proved to have dual effect of binding to both Tau and amyloid beta . According to this , we designed our clamps consists of with various linker lengths and peptides parts for further validation of this theory and analysis by wet-lab and dry lab results. According to our project Criteria , our clamps supposed to have binding affinity for tau and amyloid beta higher enough to make the inhibitor (BBa_K4165008) , (BBa_K4165010) unbind from catalytic domain of HTRA1 protease system (BBa_K4165004). | ||
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Revision as of 08:54, 8 October 2022
Clamp [15]
Clamp [14] composed of Tau Binding Peptide TD28rev (BBa_K4165006) , linker length of GGSGGGG (BBa_K4165018), Tau Binding Peptide WWW (BBa_K4165007). Our Clamp design was based on our project aim for binding with Tau and amyloid beta for further degradation.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]