Difference between revisions of "Part:BBa K4165217"

 
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Fusion protein consists of Tau binding peptide (WWW) for tau targeting and Coh2 protein [BBa_K4165003] that bind to Docs [BBa_K3396000] to form the protac system.
 
Fusion protein consists of Tau binding peptide (WWW) for tau targeting and Coh2 protein [BBa_K4165003] that bind to Docs [BBa_K3396000] to form the protac system.
  
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===Usage and Biology===
 
===Usage and Biology===
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Protac system is known to be a promising one for targeting and signaling many diseases and biological application so according to our project aim, we introduced this fusion protein with different linker length and tau binding peptide to be a target for degradation of Tau aggregation in our updated protac version system "Snitch system". Furthermore, that can be validated by wet-lab results by in vitro or in vivo testing.
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===3D Modeling and Ranking===
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<html>
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<p><img src="https://static.igem.wiki/teams/4165/wiki/parts-registry/www-ggggs.png" style="margin-left:200px;" alt="" width="500" /></p>
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</html>
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                          Figure 1.: Predicted 3D structure of CoH_(G4S)3_WWW Protein 
  
 
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Revision as of 14:23, 7 October 2022


Coh2 linked with tau binding peptide (WWW) & (G4S)3

Fusion protein consists of Tau binding peptide (WWW) for tau targeting and Coh2 protein [BBa_K4165003] that bind to Docs [BBa_K3396000] to form the protac system.

Usage and Biology

Protac system is known to be a promising one for targeting and signaling many diseases and biological application so according to our project aim, we introduced this fusion protein with different linker length and tau binding peptide to be a target for degradation of Tau aggregation in our updated protac version system "Snitch system". Furthermore, that can be validated by wet-lab results by in vitro or in vivo testing.

3D Modeling and Ranking

                         Figure 1.: Predicted 3D structure of CoH_(G4S)3_WWW Protein

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]