Difference between revisions of "Part:BBa K4165215"

Revision as of 13:28, 7 October 2022

Coh2 linked with tau binding peptide (TD28) & (G4S)3 linker

Fusion protein consists of Tau binding peptide (TD28) for tau targeting and Coh2 protein [BBa_K4165003] that bind to Docs [BBa_K3396000] to form the protac system.

Usage and Biology

Protac system is known to be a promising one for targeting and signaling many diseases and biological application so according to our project aim, we introduced this fusion protein with different linker length and tau binding peptide to be a target for degradation of Tau aggregation in our updated protac version system "Snitch system". Furthermore, that can be validated by wet-lab results by in vitro or in vivo testing.

Sequence and Features

Assembly Compatibility:

10
INCOMPATIBLE WITH RFC[10]
Illegal PstI site found at 469
12
INCOMPATIBLE WITH RFC[12]
Illegal PstI site found at 469
21
COMPATIBLE WITH RFC[21]
23
INCOMPATIBLE WITH RFC[23]
Illegal PstI site found at 469
25
INCOMPATIBLE WITH RFC[25]
Illegal PstI site found at 469
1000
COMPATIBLE WITH RFC[1000]

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 ===Usage and Biology===
+Protac system is known to be a promising one for targeting and signaling many diseases and biological application so according to our project aim, we introduced this fusion protein with different linker length and tau binding peptide to be a target for degradation of Tau aggregation in our updated protac version system "Snitch system". Furthermore, that can be validated by wet-lab results by in vitro or in vivo testing.
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