Difference between revisions of "Part:BBa K4375011"

Revision as of 09:19, 7 October 2022

Llama immunoglobulin IgA hinge linker

It is a natural llama hinge region to provide rigid linker for Nanobody and the protein fused with it. Sequence is: STPPTPSPSTPP.

Usage and Biology

This region in the antibody ensures that the variable regions can move flexibly in space and thus bind to their antigen. Since it fulfills this role in nature, it is suitable for conjugation to nanobodies. This way the Nanobody remains flexible and can attach to the chosen antigen after conjugation.

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
COMPATIBLE WITH RFC[1000]

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760621/

@@ Line 3: / Line 3: @@
 <partinfo>BBa_K4375011 short</partinfo>
-It is a natural llama hinge region to provide flexibility for Nanobody and the protein fused with it. Sequence is: STPPTPSPSTPP.
+It is a natural llama hinge region to provide rigid linker for Nanobody and the protein fused with it. Sequence is: STPPTPSPSTPP.
+==Usage and Biology==
+This region in the antibody ensures that the variable regions can move flexibly in space and thus bind to their antigen. Since it fulfills this role in nature, it is suitable for conjugation to nanobodies. This way the Nanobody remains flexible and can attach to the chosen antigen after conjugation.
-<!-- Add more about the biology of this part here
-===Usage and Biology===
 <!-- -->
@@ Line 12: / Line 15: @@
 <partinfo>BBa_K4375011 SequenceAndFeatures</partinfo>
+==References==
+https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760621/
 <!-- Uncomment this to enable Functional Parameter display