Difference between revisions of "Part:BBa K4375006"

 
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<partinfo>BBa_K4375006 short</partinfo>
 
<partinfo>BBa_K4375006 short</partinfo>
  
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CEA-specific (carcinoembryonic antigen) Nanobody is optimised for production in E. coli.
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CEA-specific (carcinoembryonic antigen) Nanobody is optimized for production in E. coli.
  
  
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==Usage and Biology==
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===Usage and Biology===
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The human carcinoembryonic antigen (CEA) is a well-studied tumor biomarkers in pancreatic cancer and is overexpressed in 83–98% of pancreatic cancers. CEA is a cell-surface glycoprotein that is normally expressed during embryogenesis, with little to no expression in normal tissue, and is used as a serum tumor marker in patients with pancreatic cancer. The Anti-CEA Nanobody recognises this tumour marker. For this reason, it is often used in a labelled form to identify tumours.
  
 
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<span class='h3bb'>Sequence and Features</span>
 
<span class='h3bb'>Sequence and Features</span>
 
<partinfo>BBa_K4375006 SequenceAndFeatures</partinfo>
 
<partinfo>BBa_K4375006 SequenceAndFeatures</partinfo>
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==References==
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138244/
  
  

Revision as of 09:10, 7 October 2022


Anti-CEA Nanobody (C43)

CEA-specific (carcinoembryonic antigen) Nanobody is optimized for production in E. coli.


Usage and Biology

The human carcinoembryonic antigen (CEA) is a well-studied tumor biomarkers in pancreatic cancer and is overexpressed in 83–98% of pancreatic cancers. CEA is a cell-surface glycoprotein that is normally expressed during embryogenesis, with little to no expression in normal tissue, and is used as a serum tumor marker in patients with pancreatic cancer. The Anti-CEA Nanobody recognises this tumour marker. For this reason, it is often used in a labelled form to identify tumours.

Sequence and Features


Assembly Compatibility:
  • 10
    INCOMPATIBLE WITH RFC[10]
    Illegal PstI site found at 244
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal PstI site found at 244
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    INCOMPATIBLE WITH RFC[23]
    Illegal PstI site found at 244
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal PstI site found at 244
  • 1000
    COMPATIBLE WITH RFC[1000]

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138244/