Difference between revisions of "Part:BBa K4165205"
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===Usage and Biology=== | ===Usage and Biology=== | ||
| + | More than 20 neurological diseases, including Alzheimer's disease, are linked to aggregated tau protein. The major parts derive these aggregations are 2 segments of VQIVYK (BBa_K4165205) and our part VQIINK. Previous Researches proved that VQIINK , located at the start of R2 repeat, is the most powerful one for deriving aggregations so many inhibitors can be designed according to this structure for inhibition of these aggregations. | ||
===3D Model=== | ===3D Model=== | ||
Revision as of 07:45, 7 October 2022
PHF asteric
Structure of the amyloid-spine from microtubule associated protein tau Repeat 2
Usage and Biology
More than 20 neurological diseases, including Alzheimer's disease, are linked to aggregated tau protein. The major parts derive these aggregations are 2 segments of VQIVYK (BBa_K4165205) and our part VQIINK. Previous Researches proved that VQIINK , located at the start of R2 repeat, is the most powerful one for deriving aggregations so many inhibitors can be designed according to this structure for inhibition of these aggregations.
3D Model
Figure 1.: RCSB Figure of PHF6*
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]