Difference between revisions of "Part:BBa K4165158"
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Revision as of 13:57, 6 October 2022
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Tau binding peptide targeting the PHF seed of Tau
Usage and Biology
P-NH peptide (NITMNSRRRRNH) is tested against PHF seed of tau (306VQIVYK311) which is found in different models of tau aggregates suggesting that it has a role in the aggregation. Findings of Gao et al, showed that P-NH can bind to PHF via van der Waal force and hydrogen bonds, it could inhibit tau hyperphosphorylation and aggregation when tested in vitro on N2a cells. In vivo, it could enhance AD mice cognitive ability.
Sequence and Features
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References
1. Zhang, X., Zhang, X., Zhong, M., Zhao, P., Guo, C., Li, Y., ... & Gao, H. (2020). Selection of a d-enantiomeric peptide specifically binding to PHF6 for inhibiting Tau aggregation in transgenic mice. ACS Chemical Neuroscience, 11(24), 4240-4253.