Difference between revisions of "Part:BBa K4165013"

 
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Ubiquitin-conjugating E2 ligase has a role in the ubiquitination cascade for protein degradation.
 
Ubiquitin-conjugating E2 ligase has a role in the ubiquitination cascade for protein degradation.
  
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===Usage and Biology===
 
===Usage and Biology===
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UBE2V2/UBE2N is a heterodimer that catalyzes the formation of poly-ubiquitin chains that lack the typical Lys-63 linkage. In this case, poly-ubiquitination does not result in proteasomal protein breakdown. Promotes the transcription of target genes. Functions as a regulator of cell cycle progression and differentiation. Helps cells recover from DNA damage by participating in the error-free DNA repair pathway.
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===Source===
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UB2V2: Q15819 in Uniprot - NP_00331.1 in NCBI
  
 
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<partinfo>BBa_K4165013 parameters</partinfo>
 
<partinfo>BBa_K4165013 parameters</partinfo>
 
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===Refrences===
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1-Komander D. (2009). The emerging complexity of protein ubiquitination. Biochemical Society transactions, 37(Pt 5), 937–953. https://doi.org/10.1042/BST0370937.
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2-David, Y., Ziv, T., Admon, A., & Navon, A. (2010). The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. The Journal of biological chemistry, 285(12), 8595–8604. https://doi.org/10.1074/jbc.M109.089003

Revision as of 13:44, 6 October 2022


UBE2V2

Ubiquitin-conjugating E2 ligase has a role in the ubiquitination cascade for protein degradation.

Usage and Biology

UBE2V2/UBE2N is a heterodimer that catalyzes the formation of poly-ubiquitin chains that lack the typical Lys-63 linkage. In this case, poly-ubiquitination does not result in proteasomal protein breakdown. Promotes the transcription of target genes. Functions as a regulator of cell cycle progression and differentiation. Helps cells recover from DNA damage by participating in the error-free DNA repair pathway.

Source

UB2V2: Q15819 in Uniprot - NP_00331.1 in NCBI

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


Refrences

1-Komander D. (2009). The emerging complexity of protein ubiquitination. Biochemical Society transactions, 37(Pt 5), 937–953. https://doi.org/10.1042/BST0370937.

2-David, Y., Ziv, T., Admon, A., & Navon, A. (2010). The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. The Journal of biological chemistry, 285(12), 8595–8604. https://doi.org/10.1074/jbc.M109.089003