Difference between revisions of "Part:BBa K4165192"

Revision as of 22:19, 5 October 2022

Amyloid beta peptide 12 (Aβ 29-42)

This part encodes a part of the Amyloid 𝛽 fragment (29-42) which has the ability to bind to A𝛽 plaques inside the brain.

Usage and Biology

Type of Amyloid-beta binding peptide start from amino acid 32 to 42, this peptide characterized by its solubility which is 22 ± 9 Um.

Features and codon optimize

This sequence is optimized for E. coli bacteria

Source

Homo sapiens Amyloid-beta precursor protein - UniProt (P05067)

References

1-Zhao, Y., Cai, J., Liu, Z., Li, Y., Zheng, C., Zheng, Y., ... & Liu, Y. (2018). Nanocomposites inhibit the formation, mitigate the neurotoxicity, and facilitate the removal of β-amyloid aggregates in Alzheimer’s disease mice. Nano letters, 19(2), 674-683.

Dry lab

Modeling

Sequence and Features