Difference between revisions of "Part:BBa K4165139"
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Tau binding peptide targeting the PHF seed of Tau | Tau binding peptide targeting the PHF seed of Tau | ||
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===Usage and Biology=== | ===Usage and Biology=== | ||
Revision as of 16:54, 5 October 2022
TLKIVW Peptide
Tau binding peptide targeting the PHF seed of Tau
Usage and Biology
TLKIVW is a hexapeptide designed using Rosetta software to bind to VQIVYK steric zipper motif of tau fibers, which is from primarily reasons for the Alzheimer’s disease and other dementia related diseases, also it can prevent further accumulation of tau fibrils.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
Dry Lab
Modeling
TLKIVW were modeled by AlphaFold2 and Apptest. The best model obtained from Apptest
Figure 1: Predicted 3D structure of Synthetic peptide TLKIVW.
Table 1: Quality assessment parameters of TLKIVW model.
References
1.Sievers, S. A., Karanicolas, J., Chang, H. W., Zhao, A., Jiang, L., Zirafi, O., ... & Eisenberg, D. (2011). Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature, 475(7354), 96-100.