Difference between revisions of "Part:BBa K4175001"
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<partinfo>BBa_K4175001 short</partinfo>
 
<partinfo>BBa_K4175001 short</partinfo>
  
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This protein domain is derived from the transmembrane part of the Notch protein. When the extracellular domain of Notch binds to its ligand Delta, the Notch core domain will undergo intramembrane proteolysis, releasing the intracellular domain. The released intracellular domain acts as a transcriptional regulator, affecting the cellular activity. The extracellular and intracellular domain can be artificially swapped, offering a tool for designing novel signaling pathways [1].
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This Notch core domain is derived from the transmembrane part of the Notch receptor. When the extracellular domain of Notch receptor binds to its ligand Delta, the Notch core domain will undergo intramembrane proteolysis. As a result, the intracellular domain of the Notch is released into the cytosol. The released intracellular domain acts as a transcriptional regulator, affecting the cellular activity. The extracellular and intracellular domain can be artificially swapped, offering a tool for designing novel signaling pathways [1].
  
 
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Revision as of 05:32, 28 August 2022


Notch core

This Notch core domain is derived from the transmembrane part of the Notch receptor. When the extracellular domain of Notch receptor binds to its ligand Delta, the Notch core domain will undergo intramembrane proteolysis. As a result, the intracellular domain of the Notch is released into the cytosol. The released intracellular domain acts as a transcriptional regulator, affecting the cellular activity. The extracellular and intracellular domain can be artificially swapped, offering a tool for designing novel signaling pathways [1].

Sequence and Features


Assembly Compatibility:
  • 10
    INCOMPATIBLE WITH RFC[10]
    Illegal PstI site found at 115
    Illegal PstI site found at 156
    Illegal PstI site found at 202
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal PstI site found at 115
    Illegal PstI site found at 156
    Illegal PstI site found at 202
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    INCOMPATIBLE WITH RFC[23]
    Illegal PstI site found at 115
    Illegal PstI site found at 156
    Illegal PstI site found at 202
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal PstI site found at 115
    Illegal PstI site found at 156
    Illegal PstI site found at 202
    Illegal NgoMIV site found at 28
  • 1000
    COMPATIBLE WITH RFC[1000]