Difference between revisions of "Part:BBa K4175003"
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<partinfo>BBa_K4175003 short</partinfo> | <partinfo>BBa_K4175003 short</partinfo> | ||
| − | This part is the intracellular domain of human programmed death-1 (PD-1). PD-1 acts as an inhibitory receptor regulating T cell effector functions. When programmed death-ligand 1 (PD-L1) and PD-L2 on the antigen-presenting cells (APCs) bind to PD-1, the intracellular domain of PD-1 will recruit phosphatases including SHP2 to downregulate some signaling pathways (e.g., PI3K-AKT pathway). Consequently, the effector T cell activity is inhibited [1]. | + | This part is the intracellular domain of human programmed death-1 (PD-1). Expressed on effector T cells, PD-1 acts as an inhibitory receptor regulating T cell effector functions. When programmed death-ligand 1 (PD-L1) and PD-L2 on the antigen-presenting cells (APCs) bind to PD-1, the intracellular domain of PD-1 will recruit phosphatases including SHP2 to downregulate some signaling pathways (e.g., PI3K-AKT pathway). Consequently, the effector T cell activity is inhibited [1]. |
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Revision as of 05:28, 28 August 2022
human intracellular PD-1
This part is the intracellular domain of human programmed death-1 (PD-1). Expressed on effector T cells, PD-1 acts as an inhibitory receptor regulating T cell effector functions. When programmed death-ligand 1 (PD-L1) and PD-L2 on the antigen-presenting cells (APCs) bind to PD-1, the intracellular domain of PD-1 will recruit phosphatases including SHP2 to downregulate some signaling pathways (e.g., PI3K-AKT pathway). Consequently, the effector T cell activity is inhibited [1].
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]