Difference between revisions of "Part:BBa K3861007"
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FimH is the distal protein found at the tip of the type 1 fimbriae.<sup>1</sup> The type 1 fimbriae plays a role in the adherence of <i> Salmonella </i> Typhimurium to the host cells, whereby mannose-containing glycoproteins can be bound by FimH. <br> | FimH is the distal protein found at the tip of the type 1 fimbriae.<sup>1</sup> The type 1 fimbriae plays a role in the adherence of <i> Salmonella </i> Typhimurium to the host cells, whereby mannose-containing glycoproteins can be bound by FimH. <br> | ||
As a part of our project "Target Taxi", we aim to fuse rBC2LCN (<a href="https://parts.igem.org/Part:BBa_K3861001">BBa_K3861001</a>), a lectin able to bind specifically to several cancer cell types, to FimH for surface display. | As a part of our project "Target Taxi", we aim to fuse rBC2LCN (<a href="https://parts.igem.org/Part:BBa_K3861001">BBa_K3861001</a>), a lectin able to bind specifically to several cancer cell types, to FimH for surface display. | ||
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Revision as of 22:31, 21 October 2021
fimH
FimH is the distal protein found at the tip of the type 1 fimbriae.1 The type 1 fimbriae plays a role in the adherence of Salmonella Typhimurium to the host cells, whereby mannose-containing glycoproteins can be bound by FimH.
As a part of our project "Target Taxi", we aim to fuse rBC2LCN (BBa_K3861001), a lectin able to bind specifically to several cancer cell types, to FimH for surface display.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
References
1. Kisiela, D. I. et al. Allosteric catch bond properties of the fimh adhesin from Salmonella enterica serovar typhimurium. J. Biol. Chem. (2011) doi:10.1074/jbc.M111.237511.