Difference between revisions of "Part:BBa K3710002"

Revision as of 20:06, 21 October 2021

UreR: urea-responsive transcriptional regulator

This part encodes the urea-responsive transcriptional regulator UreR, optimised for E. coli codon usage. Proteus mirabilis encodes the transcriptional regulator UreR of the urease gene cluster. It belongs to the AraC/XylS family of transcriptional regulators. UreR upregulates the gene clusters’ subunit transcription in the presence of urea and recruits the accessory proteins (UreDABCEFG),forming an active urease [1].

References:

[1] Poore, C. and Mobley, H. (2003) "Differential regulation of the Proteus mirabilis urease gene cluster by UreR and H-NS", Microbiology, 149(12), pp. 3383-3394.

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 <partinfo>BBa_K3710002 short</partinfo>
-Proteus mirabilis encodes the transcriptional regulator UreR of the urease gene cluster. It belongs to the AraC/XylS family of transcriptional regulators. UreR upregulates the gene clusters’ subunit transcription and recruits the accessory proteins (UreDABCEFG), in the presence of urea, to form an active urease [1,2,3].
+This part encodes the urea-responsive transcriptional regulator UreR, optimised for E. coli codon usage.
+Proteus mirabilis encodes the transcriptional regulator UreR of the urease gene cluster. It belongs to the AraC/XylS family of transcriptional regulators. UreR upregulates the gene clusters’ subunit transcription in the presence of urea and recruits the accessory proteins (UreDABCEFG),forming an active urease [1].
 References:
-[1] Poore, C. and Mobley, H. (2003) "Differential regulation of the Proteus mirabilis urease gene cluster by UreR and H-NS", Microbiology, 149(12), pp. 3383-3394. doi: 10.1099/mic.0.26624-0.
-[2] Dattelbaum, J. et al. (2003) "UreR, the Transcriptional Activator of the Proteus mirabilis Urease Gene Cluster, Is Required for Urease Activity and Virulence in Experimental Urinary Tract Infections", Infection and Immunity, 71(2), pp. 1026-1030. doi: 10.1128/iai.71.2.1026-1030.2003.
+[1] Poore, C. and Mobley, H. (2003) "Differential regulation of the Proteus mirabilis urease gene cluster by UreR and H-NS", Microbiology, 149(12), pp. 3383-3394.
-[3]. Thomas V, Collins C. Identification of UreR binding sites in the Enterobacteriaceae plasmid-encoded and Proteus mirabilis urease gene operons. Molecular Microbiology. 1999;31(5):1417-1428.