Difference between revisions of "Part:BBa K3750000"
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In C. reinhardtii, GSR is present in all cellular compartments. This part documents the cytosolic isoform of GSR in C. reinhardtii which is encoded by the gene GSHR1 (Merchant et al., 2007). | In C. reinhardtii, GSR is present in all cellular compartments. This part documents the cytosolic isoform of GSR in C. reinhardtii which is encoded by the gene GSHR1 (Merchant et al., 2007). | ||
| − | [[File:T--UNSW_Australia--GSHR1.png| | + | [[File:T--UNSW_Australia--GSHR1.png|100x80px|GSHR1 catalysis pathway]] |
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Revision as of 06:12, 21 October 2021
GSHR1 glutathione reductase (from Chlamydomonas reinhardtii)
Glutathione reductase (GSR) is a homodimeric flavoprotein (50-kDa subunits). When Glutathione (GSH) neutralises ROS, GSH becomes a radical in the form of oxidised glutathione disulfide (GSSG). GSR regulates cellular glutathione homeostasis by using NADPH and FAD to catalyze the reduction of oxidised glutathione disulfide (GSSG) into glutathione. GSR is highly conserved in aerobic organisms as it is important for cell survival when the organism is subjected to oxidative stress (Carlberg, 1985). In C. reinhardtii, GSR is present in all cellular compartments. This part documents the cytosolic isoform of GSR in C. reinhardtii which is encoded by the gene GSHR1 (Merchant et al., 2007).
Sequence and Features
- 10INCOMPATIBLE WITH RFC[10]Illegal PstI site found at 556
- 12INCOMPATIBLE WITH RFC[12]Illegal PstI site found at 556
- 21COMPATIBLE WITH RFC[21]
- 23INCOMPATIBLE WITH RFC[23]Illegal PstI site found at 556
- 25INCOMPATIBLE WITH RFC[25]Illegal PstI site found at 556
Illegal NgoMIV site found at 145
Illegal NgoMIV site found at 252 - 1000COMPATIBLE WITH RFC[1000]