Difference between revisions of "Part:BBa M10026"
 
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This part has been shown to translocate to the cell surface and adopt a multimeric conformation.  
 
This part has been shown to translocate to the cell surface and adopt a multimeric conformation.  
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It's been demonstrated to promote cell aggregation and biofilm formation on abiotic surfaces in various UPEC strains
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UpaG is a trimeric AT adhesin that mediates aggregation, biofilm formation, and adhesion to various ECM proteins.
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. UpaG is a trimeric AT adhesin that mediates aggregation, biofilm formation, and adhesion to various ECM proteins.
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In the paper, upaG was shown to: <br>
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- be located at the cell surface <br>
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- contain a C-terminal L1-β region that is a functional transporter domain <br>
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- increase both aggregation and biofilm formation when expressed in CFT073, UPEC-6, and UPEC-15 <br>
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- play a role in bacterial adherence to epithelial cells <br>
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- bind to laminin and fibronectin <br>
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[[Image:Fig1(from ref).jpg |800px]]
 
[[Image:Fig1(from ref).jpg |800px]]

Latest revision as of 20:57, 8 May 2009

{˂upaG_short!} upaG autotransporter short version

This part has been shown to translocate to the cell surface and adopt a multimeric conformation. UpaG is a trimeric AT adhesin that mediates aggregation, biofilm formation, and adhesion to various ECM proteins.

In the paper, upaG was shown to:
- be located at the cell surface
- contain a C-terminal L1-β region that is a functional transporter domain
- increase both aggregation and biofilm formation when expressed in CFT073, UPEC-6, and UPEC-15
- play a role in bacterial adherence to epithelial cells
- bind to laminin and fibronectin


Fig1(from ref).jpg

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal AgeI site found at 73
  • 1000
    COMPATIBLE WITH RFC[1000]