Difference between revisions of "Part:BBa I716152"
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This is an enzyme involved in the heme biosynthetic pathway. Also called Delta-aminolevulinate synthase | This is an enzyme involved in the heme biosynthetic pathway. Also called Delta-aminolevulinate synthase | ||
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| + | ===Information contributed by City of London UK (2021)=== | ||
| + | Part information is collated here to help future users of the BioBrick registry. | ||
| + | |||
| + | Metadata: | ||
| + | *'''Group:''' City of London UK 2021 | ||
| + | *'''Author:''' Janusan Jeyananthan | ||
| + | *'''Summary:''' Added information collated from existing scientific studies | ||
| + | |||
| + | ---- | ||
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| + | Enzyme hemA catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). When NADPH is absent, hemA exhibits substrate esterase activity, which causes the release of glutamate from tRNA. | ||
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| + | Enzyme catalytic activity: (S)-4-amino-5-oxopentanoate + NADP+ + tRNAGlu = H+ + L-glutamyl-tRNAGlu + NADPH | ||
| + | <ref>"hemA" n.d Uniprot. Accessed October 3, 2021. https://www.uniprot.org/uniprot/P0A6X1 </ref> | ||
| + | [[File:hemA.JPG|x140px|center]] | ||
| + | ===References=== | ||
| + | |||
<!-- Add more about the biology of this part here | <!-- Add more about the biology of this part here | ||
Latest revision as of 13:01, 3 October 2021
hemA (from CFT703)
This is an enzyme involved in the heme biosynthetic pathway. Also called Delta-aminolevulinate synthase
Information contributed by City of London UK (2021)
Part information is collated here to help future users of the BioBrick registry.
Metadata:
- Group: City of London UK 2021
- Author: Janusan Jeyananthan
- Summary: Added information collated from existing scientific studies
Enzyme hemA catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). When NADPH is absent, hemA exhibits substrate esterase activity, which causes the release of glutamate from tRNA.
Enzyme catalytic activity: (S)-4-amino-5-oxopentanoate + NADP+ + tRNAGlu = H+ + L-glutamyl-tRNAGlu + NADPH [1]
References
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21INCOMPATIBLE WITH RFC[21]Illegal BglII site found at 524
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
- ↑ "hemA" n.d Uniprot. Accessed October 3, 2021. https://www.uniprot.org/uniprot/P0A6X1