Difference between revisions of "Part:BBa K3897000"
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HR2 Aptamer is an 86bp ssDNA strand that can be folded into 3D shapes to target Human Epidermal Growth Factor 2 (HER2), which belongs to the Erbb receptor tyrosine kinase family. HER2 is overexpressed in some cases of breast cancer tumor cells, thus many current breast cancer drugs target this receptor either to inhibit this pathway(e.g. Herceptin), bring drugs to it proximity (ADC type drugs), or trigger immune responses (CAR-T). | HR2 Aptamer is an 86bp ssDNA strand that can be folded into 3D shapes to target Human Epidermal Growth Factor 2 (HER2), which belongs to the Erbb receptor tyrosine kinase family. HER2 is overexpressed in some cases of breast cancer tumor cells, thus many current breast cancer drugs target this receptor either to inhibit this pathway(e.g. Herceptin), bring drugs to it proximity (ADC type drugs), or trigger immune responses (CAR-T). | ||
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Revision as of 03:23, 2 October 2021
HR2 Aptamer, for targeting HER2 receptors
<h1**Introduction**</h1> HR2 Aptamer is an 86bp ssDNA strand that can be folded into 3D shapes to target Human Epidermal Growth Factor 2 (HER2), which belongs to the Erbb receptor tyrosine kinase family. HER2 is overexpressed in some cases of breast cancer tumor cells, thus many current breast cancer drugs target this receptor either to inhibit this pathway(e.g. Herceptin), bring drugs to it proximity (ADC type drugs), or trigger immune responses (CAR-T). Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]