Difference between revisions of "Part:BBa I712020"
 
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Part is involved in the activation cascade of caspases contributing to apoptosis.  
 
Part is involved in the activation cascade of caspases contributing to apoptosis.  
 
At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond  
 
At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond  
−
Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9  
+
Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9.
 
The part is also involved in the cleavage of Huntingtin (HTT gene). <ref>“CASP3 - Caspase-3 Precursor - Homo Sapiens (Human) - CASP3 Gene & Protein.” 2021. Uniprot.org. 2021. https://www.uniprot.org/uniprot/P42574.
 
The part is also involved in the cleavage of Huntingtin (HTT gene). <ref>“CASP3 - Caspase-3 Precursor - Homo Sapiens (Human) - CASP3 Gene & Protein.” 2021. Uniprot.org. 2021. https://www.uniprot.org/uniprot/P42574.
  

Latest revision as of 17:40, 1 October 2021


Homo sapiens caspase 3

Homo sapiens caspase 3, apoptosis-related cysteine peptidase (transcript variant beta).

Information contributed by City of London UK (2021)

Part information is collated here to help future users of the BioBrick registry.

Metadata:

Group: City of London UK 2021

Author: Julian Chen

Summary: Added information collated from existing scientific studies


Part is involved in the activation cascade of caspases contributing to apoptosis. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. The part is also involved in the cleavage of Huntingtin (HTT gene). [1]


Activity Regulation

Part is inhibited via isatin sulfonamides



Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


  1. ↑ “CASP3 - Caspase-3 Precursor - Homo Sapiens (Human) - CASP3 Gene & Protein.” 2021. Uniprot.org. 2021. https://www.uniprot.org/uniprot/P42574. ‌