Difference between revisions of "Part:BBa K3799004"
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<partinfo>BBa_K3799004 short</partinfo>
 
<partinfo>BBa_K3799004 short</partinfo>
  
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This antimicrobial peptide is a synthetic variant of Nisin A produced naturally in Lactococcus lactis.Mutation of Serine to proline at position 29 (S29P) combined with an isoleucine to valine substitution at position 30 (I30V) helps in making Nisin PV resistant to nisin resistant protein which is expressed on the cell surface of certain pathogenic strains like Streptococcus agalactiae which can cleave Nisin A making it less active.Nisin Pv is not only resistant to NRP but also shows enhanced antimicrobial activity against S.uberis which is a main pathogen associated with Subclinical bovine mastitis.
  
 
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Revision as of 14:44, 1 October 2021


Nisin PV, A synthetic antimicrobial peptide

This antimicrobial peptide is a synthetic variant of Nisin A produced naturally in Lactococcus lactis.Mutation of Serine to proline at position 29 (S29P) combined with an isoleucine to valine substitution at position 30 (I30V) helps in making Nisin PV resistant to nisin resistant protein which is expressed on the cell surface of certain pathogenic strains like Streptococcus agalactiae which can cleave Nisin A making it less active.Nisin Pv is not only resistant to NRP but also shows enhanced antimicrobial activity against S.uberis which is a main pathogen associated with Subclinical bovine mastitis.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]