Difference between revisions of "Part:BBa K4040001"
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====A Phagocytic receptor for apoptotic cells====
 
====A Phagocytic receptor for apoptotic cells====
  
 +
====Used for a intracellular domain of CAR====
  
 
===References===
 
===References===

Revision as of 06:57, 1 October 2021


Intracellular Domain of the MERTK Protein

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal BglII site found at 662
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI.rc site found at 13
    Illegal BsaI.rc site found at 487
    Illegal SapI.rc site found at 78

Usage and Biology

It is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. The MERTK regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Previous studies have shown that the MER tyrosine kinase (MERTK) expressed on the cytomembrane of the macrophages can not only mediate the phagocytosis of apoptotic cells and virus particles, but at the same time reduce the secretion of cytokines[1].

Background and detail description

A Phagocytic receptor for apoptotic cells

Used for a intracellular domain of CAR

References

[1]Bhattacharyya S, Zagórska A, Lew ED, Shrestha B, Rothlin CV, Naughton J, Diamond MS, Lemke G, Young JA. Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptors. Cell Host Microbe. 2013 Aug 14;14(2):136-47.