Difference between revisions of "Part:BBa K4040003"
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<partinfo>BBa_K4040003 short</partinfo> | <partinfo>BBa_K4040003 short</partinfo> | ||
| − | + | <h3><b>The structure and function of CAR ζ:</b></h3> | |
CAR ζ is another CAR aimed to increase the phagocytosis of the macrophages. And the structure is also similar to the other three CARs, with the difference in the intracellular domain which is replaced by CD ζ subunit of the T cell receptor. | CAR ζ is another CAR aimed to increase the phagocytosis of the macrophages. And the structure is also similar to the other three CARs, with the difference in the intracellular domain which is replaced by CD ζ subunit of the T cell receptor. | ||
| − | The mechanism of CAR ζ: | + | <h3><b>The mechanism of CAR ζ:</b></h3> |
The main function domain of the CAR ζ is the cytosolic Immunoreceptor Tyrosine-based Activation Motifs (ITAMs) as mentioned before. When the ligands matches its receptor, the Src family kinases will consequently be phosphorylated and thus activating the cytosolic Immunoreceptor Tyrosine-based Activation Motifs (ITAMs). The further signal pathway is the same as mentioned in CAR-MEGF10. | The main function domain of the CAR ζ is the cytosolic Immunoreceptor Tyrosine-based Activation Motifs (ITAMs) as mentioned before. When the ligands matches its receptor, the Src family kinases will consequently be phosphorylated and thus activating the cytosolic Immunoreceptor Tyrosine-based Activation Motifs (ITAMs). The further signal pathway is the same as mentioned in CAR-MEGF10. | ||
Revision as of 03:17, 3 September 2021
Intracellular Domain of CD3 zeta chain
The structure and function of CAR ζ:
CAR ζ is another CAR aimed to increase the phagocytosis of the macrophages. And the structure is also similar to the other three CARs, with the difference in the intracellular domain which is replaced by CD ζ subunit of the T cell receptor.
The mechanism of CAR ζ:
The main function domain of the CAR ζ is the cytosolic Immunoreceptor Tyrosine-based Activation Motifs (ITAMs) as mentioned before. When the ligands matches its receptor, the Src family kinases will consequently be phosphorylated and thus activating the cytosolic Immunoreceptor Tyrosine-based Activation Motifs (ITAMs). The further signal pathway is the same as mentioned in CAR-MEGF10.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]