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Revision as of 15:18, 22 October 2020

Inhibitory Sequence 1 for EPCR-PfEMP1 Interaction (4V3D)

The following characteristic properties are observed in the inhibitory peptide sequence:

• 1] Interaction Energy:-5.96088 kcal/mol

• 2] Stability Value: 7.38979 dG units

This bio brick synthesizes the inhibitory peptide sequence that is believed to bind more efficiently as Compared to the wild type sequence. The peptide sequence is built using saturated mutagenesis. In this particular mutant sequence, the amino acid of the Wild type sequence-Glutamic acid is replaced with leucine. As a result, an upgradation in its interactive properties is observed that is thought to improve its binding strength.

Figure 1.Structure of the interacting domain of PfEMP1 Protein with inhibitory peptide sequence 1.

Sequence and Features

References

1] https://www.rcsb.org/structure/4v3d