Difference between revisions of "Part:BBa K2583000"

 
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This part is the coding sequence of Histamine Receptor H4, a G-protein coupled receptor of histamine. In our project, it is used to consisted more composite part.
 
This part is the coding sequence of Histamine Receptor H4, a G-protein coupled receptor of histamine. In our project, it is used to consisted more composite part.
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==MIT MAHE 2020==
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'''Summary'''
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The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist). Histamine has long been suspected to play a role in the pathogenesis of asthma, but antihistamines that target the H1 and H2 receptors have not been shown to be effective for this condition. The use of selective ligands in animal models of asthma has now potentially filled this gap by showing a role for the H4R in mediating lung function and inflammation.
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==References==
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Thangam, E. B., Jemima, E. A., Singh, H., Baig, M. S., Khan, M., Mathias, C. B., Church, M. K., & Saluja, R. (2018). The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets. Frontiers in immunology, 9, 1873. https://doi.org/10.3389/fimmu.2018.01873
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Thurmond R. L. (2015). The histamine H4 receptor: from orphan to the clinic. Frontiers in pharmacology, 6, 65. https://doi.org/10.3389/fphar.2015.00065
  
 
<!-- Add more about the biology of this part here
 
<!-- Add more about the biology of this part here

Revision as of 18:29, 20 October 2020


HRH4_CDS

This part is the coding sequence of Histamine Receptor H4, a G-protein coupled receptor of histamine. In our project, it is used to consisted more composite part.

MIT MAHE 2020

Summary

The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist). Histamine has long been suspected to play a role in the pathogenesis of asthma, but antihistamines that target the H1 and H2 receptors have not been shown to be effective for this condition. The use of selective ligands in animal models of asthma has now potentially filled this gap by showing a role for the H4R in mediating lung function and inflammation.

References

Thangam, E. B., Jemima, E. A., Singh, H., Baig, M. S., Khan, M., Mathias, C. B., Church, M. K., & Saluja, R. (2018). The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets. Frontiers in immunology, 9, 1873. https://doi.org/10.3389/fimmu.2018.01873

Thurmond R. L. (2015). The histamine H4 receptor: from orphan to the clinic. Frontiers in pharmacology, 6, 65. https://doi.org/10.3389/fphar.2015.00065

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal BglII site found at 706
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal SapI site found at 856