Difference between revisions of "Part:BBa K3351007"

Revision as of 13:14, 19 October 2020

P6.2, an antimicrobial peptide.

P6.2 is typical linear cation α-helical peptide. Destroy the biomass membrane: 1. The combination of cationic peptide and anionic plasma membrane caused by electrostatic interaction. 2. AMP transforms from random coils to amphiphilic α helix, making Trp arranged on the same side of α helix; because of the hydrophobicity of AMP, Trp residues can be inserted into the carbon chain region of the membrane more easily, and AMP is arranged parallel to the membrane , With the accumulation of AMP binding, the outer layer of the bilayer lipid molecule layer expands and becomes thinner, destroying the plasma membrane. Due to the cationic nature of P5 and P6.2, they can be inserted between negatively charged bacterial cells, interfere with the interaction of extracellular polymers (EPS), and reduce EPS accumulation.

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
COMPATIBLE WITH RFC[1000]

@@ Line 3: / Line 3: @@
 <partinfo>BBa_K3351007 short</partinfo>
-It is a coding sequence of P6.2.
+P6.2 is typical linear cation α-helical peptide.
+Destroy the biomass membrane:
+. The combination of cationic peptide and anionic plasma membrane caused by electrostatic interaction.
+. AMP transforms from random coils to amphiphilic α helix, making Trp arranged on the same side of α helix; because of the hydrophobicity of AMP, Trp residues can be inserted into the carbon chain region of the membrane more easily, and AMP is arranged parallel to the membrane  , With the accumulation of AMP binding, the outer layer of the bilayer lipid molecule layer expands and becomes thinner, destroying the plasma membrane.
+Due to the cationic nature of P5 and P6.2, they can be inserted between negatively charged bacterial cells, interfere with the interaction of extracellular polymers (EPS), and reduce EPS accumulation.
 <!-- Add more about the biology of this part here