Difference between revisions of "Part:BBa K3582012:Design"

 
 
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===References===
 
===References===
 +
1] The structural basis for CD36 binding by the malaria parasite.
 +
Fu-Lien Hsieh1, Louise Turner2, Jani Reddy Bolla3, Carol V. Robinson3, Thomas Lavstsen2 & Matthew K. Higgins1

Latest revision as of 08:44, 15 October 2020


Inhibitory Peptide sequence 1 for CD36-PfEMP CIDRa Domain Interaction


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


Design Notes

The peptide was designed by mutating only one amino acid to ensure that the folding of the overall protein structure is not significantly disturbed.


Source

The sequence is obtained by performing saturated mutagenesis on the wild type interacting sequence of the host protein.

References

1] The structural basis for CD36 binding by the malaria parasite. Fu-Lien Hsieh1, Louise Turner2, Jani Reddy Bolla3, Carol V. Robinson3, Thomas Lavstsen2 & Matthew K. Higgins1