Revision as of 03:02, 22 October 2019

ompW Promoter

The promoter ompW is regulated by the inhibitor protein ArcA in the presence of 4mM hydrogen peroxide.

Also ompW promother is inhibited by ArcA proteim inder anaerobic conditions.

This part was obtained from Salmonella enterica

Biology

Anaerobiosis, is a predominant physiological adaptation and it is mediated by the Aerobic respiratory control B (ArcAB). The two-component system ArcA/B senses the redox status in the cytoplasmic membrane of bacteria through its membrane sensor ArcB, and upon activated, primarily represses the expression of genes involved in the aerobic carbon oxidation through its cognate response regulator ArcA which is phosphorylated under this conditions and its active. Furthermore, bacterium as Salmonella enterica must sense H2O2 and modulate gene expression. ArcA/B system plays a role in the resistance to reactive oxygen species, under high H202 concentrations ArcA is activated and some targets, as ompW promoter, are negatively regulated.

Sequence and Features