Difference between revisions of "Part:BBa K3117023"
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The single chain fragment targeting GPA33 was used to be fused to the other components of the bispecific antibody to target CD3 and GPA33. | The single chain fragment targeting GPA33 was used to be fused to the other components of the bispecific antibody to target CD3 and GPA33. | ||
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Latest revision as of 01:57, 22 October 2019
scFv VL against GPA33 codon optimized for CHO expression
The single chain variable fragment of the light chain of anti-GPA33 targets the colon cancer surface marker GPA33. Glycoprotein A33 (GPA33) is a well-known surface marker of colon cancer. Under healthy conditions GPA33 is just expressed on gastric cells. On primary and metastatic colorectal cancers, GPA33 is overexpressed in 95% of primary and colorectal cancers [1].
Usage and Biology
The single chain fragment targeting GPA33 was used to be fused to the other components of the bispecific antibody to target CD3 and GPA33.