Difference between revisions of "Part:BBa K3117022"
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<partinfo>BBa_K3117022 short</partinfo> | <partinfo>BBa_K3117022 short</partinfo> | ||
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| − | + | The single chain variable fragment of the heavy chain of anti-GPA33 targets the colon cancer surface marker GPA33. Glycoprotein A33 (GPA33) is a well-known surface marker of colon cancer. Under healthy conditions GPA33 is just expressed on gastric cells. On primary and metastatic colorectal cancers, GPA33 is overexpressed in 95% of primary and colorectal cancers [1]. | |
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===Usage and Biology=== | ===Usage and Biology=== | ||
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| + | The single chain fragment targeting GPA33 was used to be fused to the other components of the bispecific antibody to target CD3 and GPA33. | ||
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Latest revision as of 01:47, 22 October 2019
scFv VL against CD3 codon optimized for CHO expression
The single chain variable fragment of the heavy chain of anti-GPA33 targets the colon cancer surface marker GPA33. Glycoprotein A33 (GPA33) is a well-known surface marker of colon cancer. Under healthy conditions GPA33 is just expressed on gastric cells. On primary and metastatic colorectal cancers, GPA33 is overexpressed in 95% of primary and colorectal cancers [1].
Usage and Biology
The single chain fragment targeting GPA33 was used to be fused to the other components of the bispecific antibody to target CD3 and GPA33.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]