Difference between revisions of "Part:BBa K3117020"
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CD3 is co-expressed with the T cell receptor on T cells. Binding leads to downstream signaling cascades and activation of the T cell[1]. | CD3 is co-expressed with the T cell receptor on T cells. Binding leads to downstream signaling cascades and activation of the T cell[1]. | ||
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Revision as of 23:01, 21 October 2019
scFv VH against CD3 codon optimized for CHO expression
Part BBa_K3117020 is a single chain variable fragment (scFv) of the anti-CD3 antibody. This fragment was used to generate a fusion protein to create a bispecific antibody on the one hand driected against CD3, on the other part against GPA33.
Usage and Biology
CD3 is co-expressed with the T cell receptor on T cells. Binding leads to downstream signaling cascades and activation of the T cell[1].