Difference between revisions of "Part:BBa K3117021"

 
 
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<partinfo>BBa_K3117021 short</partinfo>
 
<partinfo>BBa_K3117021 short</partinfo>
  
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The single chain variable fragment of the heavy chain of anti-GPA33 targets the colon cancer surface marker GPA33. Glycoprotein A33 (GPA33) is a well-known surface marker of colon cancer. Under healthy conditions GPA33 is just expressed on gastric cells. On primary and metastatic colorectal cancers, GPA33 is overexpressed in 95% of primary and colorectal cancers [1].
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===Usage and Biology===
 
===Usage and Biology===
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The single chain fragment targeting GPA33 was used to be fused to the other components of the bispecific antibody to target CD3 and GPA33.
  
 
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Latest revision as of 22:37, 21 October 2019


scFv VH against GPA33 codon optimized for CHO expression

The single chain variable fragment of the heavy chain of anti-GPA33 targets the colon cancer surface marker GPA33. Glycoprotein A33 (GPA33) is a well-known surface marker of colon cancer. Under healthy conditions GPA33 is just expressed on gastric cells. On primary and metastatic colorectal cancers, GPA33 is overexpressed in 95% of primary and colorectal cancers [1].


Usage and Biology

The single chain fragment targeting GPA33 was used to be fused to the other components of the bispecific antibody to target CD3 and GPA33.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]